Esophageal adenocarcinoma models: a closer look.

IF 3.9 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Frontiers in Molecular Biosciences Pub Date : 2024-11-12 eCollection Date: 2024-01-01 DOI:10.3389/fmolb.2024.1440670

Nadeem Bhat, Marwah Al-Mathkour, Selma Maacha, Heng Lu, Wael El-Rifai, Farah Ballout

引用次数: 0

Abstract

Esophageal adenocarcinoma (EAC) is a subtype of esophageal cancer with significant morbidity and mortality rates worldwide. Despite advancements in tumor models, the underlying cellular and molecular mechanisms driving EAC pathogenesis are still poorly understood. Therefore, gaining insights into these mechanisms is crucial for improving patient outcomes. Researchers have developed various models to better understand EAC and evaluate clinical management strategies. However, no single model fully recapitulates the complexity of EAC. Emerging technologies, such as patient-derived organoids and immune-competent mouse models, hold promise for personalized EAC research and drug development. In this review, we shed light on the various models for studying EAC and discuss their advantages and limitations.

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食管腺癌模型：近距离观察。

食管腺癌（EAC）是食管癌的一种亚型，在全世界的发病率和死亡率都很高。尽管在肿瘤模型方面取得了进展，但人们对驱动 EAC 发病机制的潜在细胞和分子机制仍然知之甚少。因此，深入了解这些机制对于改善患者预后至关重要。研究人员开发了各种模型，以更好地了解 EAC 和评估临床管理策略。然而，没有一种模型能完全再现 EAC 的复杂性。新兴技术，如源自患者的器官组织和免疫功能健全的小鼠模型，为个性化 EAC 研究和药物开发带来了希望。在这篇综述中，我们将介绍研究 EAC 的各种模型，并讨论它们的优势和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.20

自引率

4.00%

发文量

1361

审稿时长

14 weeks

期刊介绍： Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.