Deriving comprehensive literature trends on multi-omics analysis studies in autism spectrum disorder using literature mining pipeline.

Abstract

Autism spectrum disorder (ASD) is characterized by highly heterogenous abnormalities in functional brain connectivity affecting social behavior. There is a significant progress in understanding the molecular and genetic basis of ASD in the last decade using multi-omics approach. Mining this large volume of biomedical literature for insights requires considerable amount of manual intervention for curation. Machine learning and artificial intelligence fields are advancing toward simplifying data mining from unstructured text data. Here, we demonstrate our literature mining pipeline to accelerate data to insights. Using topic modeling and generative AI techniques, we present a pipeline that can classify scientific literature into thematic clusters and can help in a wide array of applications such as knowledgebase creation, conversational virtual assistant, and summarization. Employing our pipeline, we explored the ASD literature, specifically around multi-omics studies to understand the molecular interplay underlying autism brain.