Advances in nano-delivery systems based on diagnosis and theranostics strategy for atherosclerosis.

IF 4.3 4区医学 Q1 PHARMACOLOGY & PHARMACY Journal of Drug Targeting Pub Date : 2024-11-27 DOI:10.1080/1061186X.2024.2433560

Xi Yang, Jian Hu, Quanle Gao, Yiping Deng, Yilin Liu, Xinghui He, Chuang Li, Xin Yu, Ying Wan, Chao Pi, Yumeng Wei, Chunhong Li

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Abstract

Atherosclerosis (AS) is a chronic systemic inflammatory disease, where early diagnosis and theranostics strategy for AS are crucial for improving outcomes. However, conventional diagnostic techniques are limited in identifying early AS lesions, failing to stop the progression of AS in time. Nano-delivery systems have shown significant potential in AS diagnosis and treatment, offering distinct advantages in plaque identification and enhancing drugs concentration at lesion sites, thereby advancing new-generation theranostics strategy. This review discusses the application of nano-delivery systems based on imaging technology in AS diagnosis, and we further explore recent advancements in combining different imaging technologies with emerging theranostics strategy. In addition, we also discuss the challenges faced by nano-delivery systems for AS diagnosis and theranostics in clinical translation, such as nanoparticle targeting efficiency, cytotoxicity and long-term accumulation, immune clearance and inaccurate disease modelling. Finally, we also provide prospects on nano-delivery systems based on diagnostic and therapeutic strategies.

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基于动脉粥样硬化诊断和治疗策略的纳米输送系统的进展。

动脉粥样硬化（AS）是一种慢性全身性炎症疾病，其早期诊断和治疗策略对于改善预后至关重要。然而，传统诊断技术在识别动脉粥样硬化早期病变方面存在局限性，无法及时阻止动脉粥样硬化的发展。纳米给药系统在强直性脊柱炎的诊断和治疗中显示出巨大潜力，在斑块识别和提高药物在病变部位的浓度方面具有明显优势，从而推动了新一代治疗学策略的发展。本综述讨论了基于成像技术的纳米给药系统在强直性脊柱炎诊断中的应用，并进一步探讨了将不同成像技术与新兴治疗学策略相结合的最新进展。此外，我们还讨论了用于强直性脊柱炎诊断和治疗的纳米递送系统在临床转化中面临的挑战，如纳米粒子的靶向效率、细胞毒性和长期积累、免疫清除和不准确的疾病模型。最后，我们还对基于诊断和治疗策略的纳米递送系统进行了展望。

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来源期刊

Journal of Drug Targeting 医学-药学

CiteScore

9.10

自引率

0.00%

发文量

165

审稿时长

2 months

期刊介绍： Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.