{"title":"Immune–stromal interplay shapes kidney function in health and disease","authors":"Chirag Raparia, Anne Davidson","doi":"10.1038/s41581-024-00911-4","DOIUrl":null,"url":null,"abstract":"New studies have revealed a novel homeostatic clearance function for medullary macrophages, unveiled roles for innate lymphoid cells and epithelial cells in orchestrating inflammation and fibrosis, and shown that clonal haematopoiesis influences the magnitude of inflammation in response to injury. These discoveries suggest therapeutic strategies to prevent kidney dysfunction associated with ageing and injury.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"198 1","pages":""},"PeriodicalIF":28.6000,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Nephrology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41581-024-00911-4","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
New studies have revealed a novel homeostatic clearance function for medullary macrophages, unveiled roles for innate lymphoid cells and epithelial cells in orchestrating inflammation and fibrosis, and shown that clonal haematopoiesis influences the magnitude of inflammation in response to injury. These discoveries suggest therapeutic strategies to prevent kidney dysfunction associated with ageing and injury.
期刊介绍：
Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves.
It strives to publish authoritative, accessible articles.
Articles are enhanced with clearly understandable figures, tables, and other display items.
Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements.
The content is relevant to nephrologists and basic science researchers.
The broad scope of the journal ensures that the work reaches the widest possible audience.
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