Synthesis, characterization, antimicrobial activity of 2-amino-5-picoline and dipicolinic acid of Ni(II) and Cu(II) metal complexes

IF 2.2 4区化学 Q2 Engineering Chemical Papers Pub Date : 2024-10-24 DOI:10.1007/s11696-024-03736-4

Halil İlkimen, Sabiha Gözde Salün, Aysel Gülbandılar, Musa Sarı

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Abstract

Ni(II) {(2a5p)₂[Ni(OH₂)₆][Ni(dipic)₂]₂.2H₂O, 1} and Cu(II) {[Cu(dipic)(2a5p)(H₂O)].H₂O, 2} complexes obtained from 2-amino-5-picoline (2a5p) with dipicolinic acid (H₂dipic) and Cu(II) complex {[(H₂O)(dipic)Cu(OH)Cu(OH)(H₂O)₂Cu(dipic)(H₂O)].2H₂O, 3} of H₂dipic have been synthesized and characterized by atomic absorption spectroscopy (AAS), ultraviolet–visible region (UV–Vis), Fourier transform infrared spectroscopy (FT-IR), conductivity measurement, magnetic measurement and X-ray crystallography. Furthermore, antimicrobial properties of starting and syntheses complexes have also been tested against C. krusei (ATCC 6258), C. albicans (ATCC 14053) and C. parapsilosis (ATCC 22019) (yeast) for antifungal activity and E. faecalis (ATCC 29212), E. coli (ATCC 25922) and S. aureus (ATCC 29213) for antibacterial activity. The antimicrobial activities of results were compared to those of standard agents such as fluconazole, levofloxacin, cefepime and vancomycin.

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2-amino-5-picoline 和 dipicolinic acid 的 Ni(II) 和 Cu(II) 金属配合物的合成、表征和抗菌活性

Ni(II) {(2a5p)2[Ni(OH2)6][Ni(dipic)2]2.2H2O, 1} 和 Cu(II) {[Cu(dipic)(2a5p)(H2O)].H2O，2}络合物由 2-氨基-5-甲基吡啶（2a5p）与二吡啶甲酸（H2dipic）和 Cu（II）络合物{[(H2O)(dipic)Cu（OH）Cu（OH）（H2O）2Cu（dipic）（H2O）].2H2O, 3} ，并通过原子吸收光谱（AAS）、紫外-可见光谱（UV-Vis）、傅立叶变换红外光谱（FT-IR）、电导率测量、磁性测量和 X 射线晶体学进行了表征。此外，还测试了起始化合物和合成复合物的抗菌特性，包括针对克鲁塞酵母菌（ATCC 6258）、白僵菌（ATCC 14053）和副酵母菌（ATCC 22019）的抗真菌活性，以及针对粪肠球菌（ATCC 29212）、大肠杆菌（ATCC 25922）和金黄色葡萄球菌（ATCC 29213）的抗菌活性。实验结果与氟康唑、左氧氟沙星、头孢吡肟和万古霉素等标准药物的抗菌活性进行了比较。

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来源期刊

Chemical Papers Chemical Engineering-General Chemical Engineering

CiteScore

3.30

自引率

4.50%

发文量

590

期刊介绍： Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.