Mark A Bernard, Allal Boutajangout, Ludovic Debure, Wajiha Ahmed, Anthony Q Briggs, Carolina Boza-Calvo, Alok Vedvyas, Karyn Marsh, Omonigho M Bubu, Ricardo S Osorio, Thomas Wisniewski, Arjun V Masurkar
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引用次数: 0
Abstract
Anxiety is highly prevalent in Alzheimer's disease (AD), correlating with cerebrospinal fluid/positron emission tomography biomarkers and disease progression. Relationships to plasma biomarkers are unclear. Herein, we compare levels of plasma biomarkers in research participants with and without anxiety at cognitively normal, mild cognitive impairment, and AD dementia stages. We observed significantly higher plasma tau/amyloid-β42 ratio in AD participants with anxiety versus those without, but did not observe differences at other stages or plasma biomarkers. No such relationships were evident with depression. These results support a unique pathophysiological relationship between anxiety and AD that can be reflected in plasma biomarkers, suggestive of heightened neurodegeneration.
焦虑在阿尔茨海默病（AD）中非常普遍，与脑脊液/正电子发射断层扫描生物标志物和疾病进展相关。与血浆生物标志物的关系尚不清楚。在此，我们比较了有焦虑和无焦虑的研究参与者在认知正常、轻度认知障碍和 AD 痴呆阶段的血浆生物标志物水平。我们观察到，患有焦虑症的 AD 患者血浆中 tau/淀粉样蛋白-β42比率明显高于未患有焦虑症的患者，但在其他阶段或血浆生物标志物中未观察到差异。抑郁症患者与焦虑症患者之间没有明显的关系。这些结果支持焦虑与渐冻症之间存在一种独特的病理生理学关系，这种关系可反映在血浆生物标志物中，表明神经变性加剧。
期刊介绍：
The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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