Risk of atrial fibrillation in patients with inflammatory bowel disease: A systematic review and meta-analysis

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS IJC Heart and Vasculature Pub Date : 2024-12-01 DOI:10.1016/j.ijcha.2024.101531

Yangyang Ke , Wengen Zhu , Wulamiding Kaisaier , Yili Chen

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Abstract

Background

Several studies have reported the association between inflammatory bowel disease (IBD) and the risk of atrial fibrillation (AF). This systematic review and meta-analysis aimed to determine the prevalence and incidence of AF in the IBD population.

Methods

We conducted a systematic search of the PubMed and Embase databases for relevant studies published up to February 2024. We used the random-effects model to pool the prevalence and incidence rates of AF among IBD patients. The subgroup analyses were performed according to the IBD type.

Results

A total of twenty-five studies were included. The pooled prevalence of AF among IBD patients was 6.23 % (95 % confidence interval [CI]: 4.99 %−7.47 %). The incidence rate of AF among IBD patients was 3.53 % (95 % CI: 0.57 %−6.48 %). The risk of developing AF in IBD patients was 1.45 times higher than that in the general population (risk ratio [RR]: 1.45, 95 % CI: 1.21–1.73). When comparing specific IBD types to the general population, the RR was 1.35 (95 % CI: 1.11–1.64) for CD and 1.17 (95 % CI: 1.11–1.23) for UC.

Conclusions

Our findings suggest that IBD patients exhibit an increased risk of developing AF compared to the general population. CD patients have a higher AF incidence compared to UC patients.

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炎症性肠病患者心房颤动的风险：一项系统回顾和荟萃分析

一些研究报道了炎症性肠病（IBD）与心房颤动（AF）风险之间的关联。本系统综述和荟萃分析旨在确定心房颤动在IBD人群中的患病率和发病率。方法系统检索PubMed和Embase数据库中截至2024年2月发表的相关研究。我们使用随机效应模型汇总IBD患者房颤的患病率和发病率。根据IBD类型进行亚组分析。结果共纳入25项研究。IBD患者AF的总患病率为6.23%（95%可信区间[CI]: 4.99% ~ 7.47%）。IBD患者房颤发生率为3.53% （95% CI: 0.57% ~ 6.48%）。IBD患者发生房颤的风险是普通人群的1.45倍（风险比[RR]: 1.45, 95% CI: 1.21-1.73）。当将特定IBD类型与一般人群进行比较时，CD的RR为1.35 (95% CI: 1.11-1.64)， UC的RR为1.17 （95% CI: 1.11-1.23）。结论：研究结果表明，IBD患者发生房颤的风险高于普通人群。与UC患者相比，CD患者有更高的AF发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

10.30%

发文量

216

审稿时长

56 days

期刊介绍： IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.