Fluorescent sensing for boronic acid derivatives: Design, synthesis, mechanism, application and perspective in Boron Neutron Capture Therapy (BNCT)

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED Dyes and Pigments Pub Date : 2024-11-26 DOI:10.1016/j.dyepig.2024.112561

Yuanfeng Qi , Wenwen Sun , Le Wang , Xiao Zhang , Xuetao Wu , Yingbo Li , Junfeng Wang

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Abstract

Boron is ubiquitous in nature, and drugs based on boronic acid and esters are now widely developed and used. Boron Neutron Capture Therapy (BNCT), with its high selectivity in targeting cancer cells while minimizing damage to healthy tissues, is currently an innovative cancer treatment technology being explored worldwide. The treatment process of BNCT primarily involves delivering targeted ¹⁰B drugs to the tumor site. After neutron irradiation, the ¹⁰B drugs will absorb neutrons and undergo nuclear transformation into ¹¹B which subsequently decays to produce ⁷Li and alpha particles, thereby damaging DNA and killing cancer cells. The concentration and location of the ¹⁰B drugs delivered to tumor cells are critical determinants of the therapeutic effect of BNCT, making the sensing of boronic acid drugs particularly important. In this review, the design and synthesis of various boronic acid sensors with different chelating ligands were discussed, as well as the applications in BNCT. Finally, we analyze the current limitations and propose future perspectives for these sensors to improve their utility in biomedical applications.

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.