Xiaoxu Mu, Yi Wu, Yusheng Pu, Jinghua Ruan, Xin Zha, Suo Gao, Bing Wang, Jianta Wang, Lei Tang, Cong Wang
{"title":"Copper-Catalyzed Regioselective Reaction for Arylselenation of Unprotected Pyrazoles Using Selenium Powder","authors":"Xiaoxu Mu, Yi Wu, Yusheng Pu, Jinghua Ruan, Xin Zha, Suo Gao, Bing Wang, Jianta Wang, Lei Tang, Cong Wang","doi":"10.1002/slct.202403594","DOIUrl":null,"url":null,"abstract":"<p>A new and convenient Cu-catalyzed three-component reaction of N-unsubstituted pyrazoles with Se powder and aryl iodides has been established. The protocol presents a broad substrate scope, good functional group tolerance, and high regioselectivity. The utility of this procedure is further established by gram-scale synthesis as well as the diversified transformations of 4-organylselanyl-1<i>H</i>-pyrazoles to useful compounds.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 45","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemistrySelect","FirstCategoryId":"92","ListUrlMain":"https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202403594","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A new and convenient Cu-catalyzed three-component reaction of N-unsubstituted pyrazoles with Se powder and aryl iodides has been established. The protocol presents a broad substrate scope, good functional group tolerance, and high regioselectivity. The utility of this procedure is further established by gram-scale synthesis as well as the diversified transformations of 4-organylselanyl-1H-pyrazoles to useful compounds.
期刊介绍:
ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.