Yu-Ting Wang, Yuan Dong, Fang Wang, Shuai-Ming Zhu, Yang Zhang, Yu Yang, Rui Xu, Cai-Hong Dong, You-Zhi Zhang, Chang-Wei Li
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引用次数: 0
Abstract
Four previously undescribed caryophyllene sesquiterpenoids (1-4) along with one known drimane sesquiterpenoid (5) were isolated from the fermentation products of the mushroom Hypholoma capnoides 819. The structures of 1-4 with rare tricyclic skeleton (6/5/4) or bicyclic skeletons (9/4) were determined on the basis of comprehensive spectroscopic data analysis, calculated NMR, ORD data and their biosynthetic pathways. Compounds 1-5 only showed very weak cytotoxicity towards mouse microglial cells (BV2), breast cancer cells (MCF-7) and human lung cancer cells (A549) at 40 μM. Additionally, none of the compounds demonstrated antibacterial activity against Staphylococcus aureus or Escherichia coli at 128 μg/mL.
期刊介绍：
Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level.
Since 2017, Chemistry & Biodiversity is published in an online-only format.
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