Alexander A. Kirichok, Hennadii Tkachuk, Kostiantyn Levchenko, Dmitry Granat, Tetyana Yegorova, Dmytro Lesyk, Anna Anisiforova, Yuliia Holota, Viktoriia Zomchak, Iryna Bodenchuk, Viktoriia Kosach, Petro Borysko, Rodion A. Korzh, Galeb Al-Maali, Vladimir Kubyshkin, Henry S. Rzepa, Pavel K. Mykhailiuk
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引用次数: 0
Abstract
The previously neglected “angular” spirocyclic azetidines have been synthesized, characterized, and validated in drug discovery. We have shown that these compounds could act as bioisosteres for common saturated six-membered heterocycles. Their incorporation into the structure of the anticancer drug Sonidegib (instead of morpholine), and Danofloxacine (instead of piperazine) provided novel patent-free analogs with similar physicochemical properties and high activity.
期刊介绍：
Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.
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