Tritium labelling of several potent imidazoline receptor ligands

Abstract

The concept of biological receptors is now more than a century old with numerous receptor families being identified as they respond to the influence of a collection of agonist and antagonist substances. Many receptors have been fully studied and characterized. However, the imidazoline receptor family is one of the more intriguing groups for which unanswered biology questions still remain. To better understand the imidazoline receptors, this work describes the synthesis and characterization of several useful tritium labelled imidazoline radioligands.