{"title":"New flavonoid glycosides from the stems and leaves of Astragalus membranaceus.","authors":"Jin-Yan Tan, Jia-Xin Zhao, Yun Zang, Pei Li, Si-Qi Yang, Xiao-Mao Li, Ying-Li Wang, Yan-Gang Cheng","doi":"10.1016/j.fitote.2024.106321","DOIUrl":null,"url":null,"abstract":"<p><p>Astragalus membranaceus, a well-known traditional medicine and food, has been extensively studied for its roots. However, comparatively little attention has been paid to its stems and leaves. In this study, we successfully isolated and identified three new flavonoid glycosides (1-3), and eight known analogues (4-11) from the stems and leaves of A. membranaceus. Notably, compound 10 exhibited significant anti-inflammatory activities in LPS-induced BV2 cells, with IC<sub>50</sub> value of 1.11 ± 0.04 μM. These findings highlight flavonoids as the key bioactive components present in the stems and leaves of A. membranaceus.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106321"},"PeriodicalIF":2.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.fitote.2024.106321","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/3 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Astragalus membranaceus, a well-known traditional medicine and food, has been extensively studied for its roots. However, comparatively little attention has been paid to its stems and leaves. In this study, we successfully isolated and identified three new flavonoid glycosides (1-3), and eight known analogues (4-11) from the stems and leaves of A. membranaceus. Notably, compound 10 exhibited significant anti-inflammatory activities in LPS-induced BV2 cells, with IC50 value of 1.11 ± 0.04 μM. These findings highlight flavonoids as the key bioactive components present in the stems and leaves of A. membranaceus.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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