{"title":"New ent-cleistanthanes and ent-pimaras diterpenoids with potential cytotoxicity from Phyllanthus franchetianus H. Lév.","authors":"Ying Xin, Wang-Hui Niu, Jia-Huan Shang, Na Li, Hong-Tao Zhu, Xiao-Nian Li, Xing-Zhi Yang, Ying-Jun Zhang","doi":"10.1016/j.fitote.2024.106334","DOIUrl":null,"url":null,"abstract":"<p><p>Seven diterpenoids including five ent-cleistanthanes (1, 2, 4-6) and two ent-pimaranes (3, 7) were isolated for the first time from the aerial part of Phyllanthus franchetianus H. Lév. Their structures were elucidated on the basis of the extensive spectroscopic analyses, single-crystal X-ray diffraction and ECD analysis. Phyllanthanes A-C (1-3) are new compounds. Notably, the ent-cleistanthanes 1 and 4-5 exhibited moderate cytotoxicity against five human cancer (HL-60, A549, HepG2, MDA-MB-231, SW480) (IC<sub>50</sub> = 5.01-32.41 μM) and one normal BEAS-2B (IC<sub>50</sub> = 20.45-24.33 μM) cell lines.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106334"},"PeriodicalIF":2.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.fitote.2024.106334","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/3 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Seven diterpenoids including five ent-cleistanthanes (1, 2, 4-6) and two ent-pimaranes (3, 7) were isolated for the first time from the aerial part of Phyllanthus franchetianus H. Lév. Their structures were elucidated on the basis of the extensive spectroscopic analyses, single-crystal X-ray diffraction and ECD analysis. Phyllanthanes A-C (1-3) are new compounds. Notably, the ent-cleistanthanes 1 and 4-5 exhibited moderate cytotoxicity against five human cancer (HL-60, A549, HepG2, MDA-MB-231, SW480) (IC50 = 5.01-32.41 μM) and one normal BEAS-2B (IC50 = 20.45-24.33 μM) cell lines.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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