Endothelial Cell-Derived Extracellular Vesicles Allow to Differentiate Between Various Endotypes of INOCA: A Multicentre, Prospective, Cohort Study.

IF 2.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiovascular Translational Research Pub Date : 2024-12-05 DOI:10.1007/s12265-024-10575-x

Aleksandra Gąsecka, Piotr Szolc, Edwin van der Pol, Łukasz Niewiara, Bartłomiej Guzik, Paweł Kleczyński, Mariusz Tomaniak, Emilia Figura, Mateusz Zaremba, Marcin Grabowski, Janusz Kochman, Jacek Legutko, Łukasz Kołtowski

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Abstract

Ischemia and non-obstructive coronary artery disease (INOCA) might be due to coronary microvascular dysfunction (CMD), vasospastic angina (VSA) or both. We compared plasma concentration of various extracellular vesicles (EVs) in patients with different INOCA endotypes. Patients were divided into those with INOCA (CMD, VSA, mixed CMD + VSA) and non-anginal chest pain. Plasma concentrations of EVs were measured using flow cytometry. Out of 96 patients included, 34 had CMD (35%), 15 VSA (16%), 24 mixed endotype (25%) and 23 non-anginal chest pain (24%). Patients with INOCA had lower ratio of endothelial EVs (CD144 +) to total EVs, compared to patients with non-anginal pain (p = 0.027). Patients with mixed endotype had lower ratio of endothelial EVs (CD144 +) to total EVs, compared to CMD (p = 0.008), VSA (p = 0.014) and non-anginal pain (p < 0.001). Decreased ratio of endothelial EVs (CD144 +) to total EVs might serve as a "circulating footprint" of the mixed INOCA endotype.

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内皮细胞来源的细胞外囊泡允许区分不同的内皮类型：一项多中心、前瞻性、队列研究。

缺血和非阻塞性冠状动脉疾病（INOCA）可能是由于冠状动脉微血管功能障碍（CMD）、血管痉挛性心绞痛（VSA）或两者兼而有之。我们比较了不同INOCA内型患者各种细胞外囊泡（EVs）的血浆浓度。患者分为inova组（CMD、VSA、CMD + VSA混合组）和非心绞痛性胸痛组。采用流式细胞术检测血浆中ev浓度。96例患者中，CMD 34例（35%），VSA 15例（16%），混合型24例（25%），非心绞痛性胸痛23例（24%）。与非心绞痛患者相比，INOCA患者内皮内皮细胞（CD144 +）占总内皮细胞的比例较低（p = 0.027）。与CMD （p = 0.008）、VSA （p = 0.014）和非心绞痛（p = 0.014）相比，混合内窥法患者内皮细胞内皮细胞（CD144 +）占总内皮细胞的比例较低

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来源期刊

Journal of Cardiovascular Translational Research CARDIAC & CARDIOVASCULAR SYSTEMS-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.10

自引率

2.90%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research. JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials. JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.