Case Report: Buprenorphine for Palliation in a Patient with End Stage Renal Disease.

Sing Ping Chow, Scott Donelenko, Chris Coppock
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Abstract

End stage renal disease (ESRD) is known to be associated with pain, malaise and decreased quality of life. Pain management in the setting of dialysis is particularly challenging from a pharmacologic standpoint given altered pharmacokinetics of pain medications. Buprenorphine, a partial mu opioid receptor agonist, demonstrates superior safety profile compared to full mu opioid receptor agonists. In this case report, we demonstrated buprenorphine buccal film (Belbuca) as a safe and effective opioid treatment option for pain palliation in a dialysis dependent patient. Future studies may be warranted with larger sample size and longer follow up period to study the effect of buprenorphine in the setting of hemodialysis and non-dialysis dependent ESRD population.

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病例报告:丁丙诺啡对终末期肾病患者的缓解作用。
终末期肾病(ESRD)与疼痛、不适和生活质量下降有关。考虑到疼痛药物的药代动力学改变,从药理学角度来看,透析患者的疼痛管理尤其具有挑战性。丁丙诺啡是一种部分阿片受体激动剂,与全阿片受体激动剂相比,具有更高的安全性。在本病例报告中,我们证明丁丙诺啡颊膜(Belbuca)是一种安全有效的阿片类药物治疗方案,用于缓解透析依赖患者的疼痛。未来的研究可能需要更大的样本量和更长的随访时间来研究丁丙诺啡在血液透析和非透析依赖ESRD人群中的作用。
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来源期刊
CiteScore
1.60
自引率
9.10%
发文量
40
期刊最新文献
The Gravedigger. Comparing Maintenance Therapy Achievement for Opioid-Experienced Patients Converted to Buprenorphine for Chronic Pain Management. Retrospective Observational Descriptive Study on Use and Rotations to Belbuca®. Successful Initiation of Buprenorphine for Chronic Non-Cancer Pain in an Opioid-Experienced Patient: A Case Report. UK Medical Cannabis Registry: An Analysis of Clinical Outcomes of Medicinal Cannabis Therapy for Cancer Pain.
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