The relationship of serum klotho levels and triglyceride glucose index-related indicators.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Lipids in Health and Disease Pub Date : 2024-12-05 DOI:10.1186/s12944-024-02379-4

Yaoyao Zhou, Yaqi Wang, Fangli Li, Yiming Shi, Taotao Wu, Yingshuai Li

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Abstract

Background: Klotho, an anti-aging protein, is linked to energy metabolism. There is limited research on the association of serum klotho and triglyceride glucose (TyG) index-related indicators. Our research aims to investigate the relationship of serum klotho with TyG-BMI (body mass index), TyG-WC (waist circumference), and TyG-WHtR (waist-to-height ratio).

Methods: From 2007 to 2016, we examined 6,370 participants in the National Health and Nutrition Examination Survey (NHANES). The enzyme-linked immunosorbent assay (ELISA) was utilized to measure serum klotho. We calculated the TyG-BMI, TyG-WC, and TyG-WHtR based on fasting triglycerides, fasting glucose, BMI, WC, and WHtR. Multiple linear regression analysis was used to evaluate the association of serum klotho with TyG-BMI, TyG-WC, and TyG-WHtR. Additionally, generalized additive model (GAM) and smoothing curves were used to evaluate the linear and nonlinear relationships. A piecewise regression model was also utilized to test for threshold effects and determine the breakpoints. Finally, the potential independent associations of serum klotho with TyG-BMI, TyG-WC, and TyG-WHtR were further explored using subgroup analysis.

Results: We observed a statistically significant difference in serum klotho levels across different quartiles of the population. Based on the multiple linear regression analysis, serum klotho levels were negatively associated with TyG-related indicators. There was a nonlinear relationship between the serum klotho and TyG-BMI, TyG-WC, and TyG-WHtR. The segmented regression analysis revealed that the breakpoints of TyG-BMI, TyG-WC, and TyG-WHtR were 5.42, 6.67, and 1.89, respectively. Subgroup analysis showed that TyG-related indicators interacted with gender and diabetes.

Conclusions: In this study, a negative and nonlinear relationship was identified between serum klotho and TyG-related indicators. Further research is needed to clarify the potential mechanisms that may link serum klotho to TyG-BMI, TyG-WC, and TyG-WHtR.

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血清klotho水平与甘油三酯葡萄糖指标相关指标的关系。

背景：Klotho是一种抗衰老蛋白，与能量代谢有关。目前对血清klotho与甘油三酯葡萄糖（TyG）指数相关指标的相关性研究有限。本研究旨在探讨血清klotho与体质指数（TyG-BMI）、腰围（TyG-WC）、腰高比（TyG-WHtR）的关系。方法：从2007年到2016年，我们对6370名参加国家健康与营养检查调查（NHANES）的参与者进行了调查。采用酶联免疫吸附试验（ELISA）测定血清氯索素（klotho）。我们根据空腹甘油三酯、空腹血糖、BMI、WC和WHtR计算TyG-BMI、TyG-WC和TyG-WHtR。采用多元线性回归分析评价血清klotho与TyG-BMI、TyG-WC、TyG-WHtR的相关性。此外，采用广义加性模型（GAM）和平滑曲线来评估线性和非线性关系。一个分段回归模型也被用来测试阈值效应和确定断点。最后，通过亚组分析进一步探讨血清klotho与TyG-BMI、TyG-WC和TyG-WHtR的潜在独立关联。结果：我们观察到不同四分位数人群的血清klotho水平有统计学上的显著差异。经多元线性回归分析，血清klotho水平与tyg相关指标呈负相关。血清klotho与TyG-BMI、TyG-WC、TyG-WHtR呈非线性关系。分段回归分析显示，TyG-BMI、TyG-WC和TyG-WHtR的断点分别为5.42、6.67和1.89。亚组分析显示，tyg相关指标与性别和糖尿病存在交互作用。结论：本研究发现血清klotho与tyg相关指标呈非线性负相关关系。需要进一步的研究来阐明血清klotho与TyG-BMI、TyG-WC和TyG-WHtR之间的潜在联系机制。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.