Jessica Loo, Marc Robbins, Carson McNeil, Tadayuki Yoshitake, Charles Santori, Chuanhe Jay Shan, Saurabh Vyawahare, Hardik Patel, Tzu Chien Wang, Robert Findlater, David F Steiner, Sudha Rao, Michael Gutierrez, Yang Wang, Adrian C Sanchez, Raymund Yin, Vanessa Velez, Julia S Sigman, Patricia Coutinho de Souza, Hareesh Chandrupatla, Liam Scott, Shamira S Weaver, Chung-Wein Lee, Ehud Rivlin, Roman Goldenberg, Suzana S Couto, Peter Cimermancic, Pok Fai Wong
{"title":"Autofluorescence Virtual Staining System for H&E Histology and Multiplex Immunofluorescence Applied to Immuno-Oncology Biomarkers in Lung Cancer.","authors":"Jessica Loo, Marc Robbins, Carson McNeil, Tadayuki Yoshitake, Charles Santori, Chuanhe Jay Shan, Saurabh Vyawahare, Hardik Patel, Tzu Chien Wang, Robert Findlater, David F Steiner, Sudha Rao, Michael Gutierrez, Yang Wang, Adrian C Sanchez, Raymund Yin, Vanessa Velez, Julia S Sigman, Patricia Coutinho de Souza, Hareesh Chandrupatla, Liam Scott, Shamira S Weaver, Chung-Wein Lee, Ehud Rivlin, Roman Goldenberg, Suzana S Couto, Peter Cimermancic, Pok Fai Wong","doi":"10.1158/2767-9764.CRC-24-0327","DOIUrl":null,"url":null,"abstract":"<p><strong>Significance: </strong>We extend the capabilities of virtual staining from AF to a different disease and stain modality. Our work includes newly developed virtual stains for H&E and a multiplex immunofluorescence panel (DAPI, PanCK, PD-L1, CD3, and CD8) for non-small cell lung cancer, which reproduce the key features of real stains.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"54-65"},"PeriodicalIF":2.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707747/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/2767-9764.CRC-24-0327","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Significance: We extend the capabilities of virtual staining from AF to a different disease and stain modality. Our work includes newly developed virtual stains for H&E and a multiplex immunofluorescence panel (DAPI, PanCK, PD-L1, CD3, and CD8) for non-small cell lung cancer, which reproduce the key features of real stains.