{"title":"Identification of distinct types of steatotic liver disease with specific clinical trajectories","authors":"","doi":"10.1038/s41591-024-03366-z","DOIUrl":null,"url":null,"abstract":"In a cluster analysis study, we identified two types of metabolic dysfunction-associated steatotic liver disease (MASLD) characterized by distinct clinical trajectories. The two types of MASLD show similar liver histology, but one is liver-specific with low cardiovascular risk while the other has high cardiovascular risk and high metabolic risk.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"27 1","pages":""},"PeriodicalIF":58.7000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41591-024-03366-z","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In a cluster analysis study, we identified two types of metabolic dysfunction-associated steatotic liver disease (MASLD) characterized by distinct clinical trajectories. The two types of MASLD show similar liver histology, but one is liver-specific with low cardiovascular risk while the other has high cardiovascular risk and high metabolic risk.
期刊介绍：
Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors.
Nature Medicine consider all types of clinical research, including:
-Case-reports and small case series
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-Observational studies
-Meta-analyses
-Biomarker studies
-Public and global health studies
Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.
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