Unveiling the biological functions and therapeutic potentials of LONP1 in the ovary.

IF 12.8 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in molecular medicine Pub Date : 2024-12-07 DOI:10.1016/j.molmed.2024.11.010
Yi Chen, Weian Mao, Yanting Shen, Honing Huang, Hsun-Ming Chang, Xi Dong, Jingjing Jiang, Liangshan Mu
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Abstract

Recent research highlights that Lon protease 1 (LONP1) regulates steroidogenesis in the ovary and plays a role in oocyte development and quality control. Dysregulation of LONP1 has been observed in polycystic ovary syndrome and ovarian aging. This forum article explores the role of LONP1 in the ovary and its therapeutic potential.

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揭示LONP1在卵巢中的生物学功能和治疗潜力。
最近的研究表明,Lon蛋白酶1 (LONP1)在卵巢中调节甾体生成,并在卵母细胞发育和质量控制中发挥作用。在多囊卵巢综合征和卵巢衰老中发现了LONP1的失调。这篇论坛文章探讨了LONP1在卵巢中的作用及其治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in molecular medicine
Trends in molecular medicine 医学-生化与分子生物学
CiteScore
24.60
自引率
0.00%
发文量
142
审稿时长
6-12 weeks
期刊介绍: Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.
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