Immunoarchitectural Pattern and Its Potential Prognostic Value in Mucoepidermoid Carcinoma.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2025-06-01 Epub Date: 2024-12-09 DOI:10.1111/odi.15216

Vy Ngoc Thuy Tran, Komkrit Ruangritchankul, Nikolaos G Nikitakis, Somponnat Sampattavanich, Joao N Ferreira, Risa Chaisuparat

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Abstract

Objectives: To define tumor immunoarchitectural patterns (IPs) and characterize the immune profile in salivary gland mucoepidermoid carcinoma (MEC) toward assessing MEC prognostic significance and implications for immunotherapy.

Methods: This study analyzed 41 MEC cases, evaluating the tumor IPs and tumor-infiltrating lymphocyte (TIL) parameters by using whole-slide imaging and AI-assisted assessment. Immunohistochemistry of CD3 and CD8 markers was performed to assess key lymphocyte subpopulations.

Results: Immune-rich (I-rich) tumors were characterized by high TIL density and were associated with aggressive tumor behavior, particularly in histological high-grade MEC, with a significant increase in TIL density observed in the inner invasive margin compartment (p < 0.05). I-rich tumor cases were linked to poorer disease-free survival (DFS) (Breslow = 4.686, p = 0.03). Aggressive MEC cases displayed a highly heterogeneous TIL profile, however, no TIL patterns showed a significant impact on DFS (p > 0.05).

Conclusions: Despite the high immunogenicity suggested by the abundance of T lymphocytes, the protective role of CD8+ T lymphocytes was not prominent in MEC. I-rich tumors appeared more aggressive and unfavorable MEC cases exhibited high heterogeneity in their TIL profiles. Interrogating the role of TILs in the inner invasive tumor margin may offer a new mechanistic understanding for future immunotherapy discovery.

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黏液表皮样癌的免疫结构模式及其潜在预后价值。

目的：确定涎腺黏液表皮样癌（MEC）的肿瘤免疫结构模式（IPs）和免疫谱特征，以评估MEC的预后意义和免疫治疗的意义。方法：本研究对41例MEC患者进行分析，采用全片显像和人工智能辅助评估，评估肿瘤IPs和肿瘤浸润淋巴细胞（TIL）参数。免疫组化CD3和CD8标记物评估关键淋巴细胞亚群。结果：富含免疫（I-rich）的肿瘤以高TIL密度为特征，并与肿瘤的侵袭性行为相关，特别是在组织学上高级别MEC中，在侵袭性内缘腔室观察到TIL密度显著增加（p 0.05）。结论：尽管T淋巴细胞的丰度表明其具有较高的免疫原性，但CD8+ T淋巴细胞在MEC中的保护作用并不突出。富含i的肿瘤更具侵袭性，不利的MEC病例在TIL谱上表现出高度的异质性。探究TILs在侵袭性肿瘤内缘的作用可能为未来免疫治疗的发现提供新的机制理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.