Diels-Alder reaction in hydrogel synthesis: Mechanisms and functional aspects.

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL Journal of Biomaterials Applications Pub Date : 2024-12-13 DOI:10.1177/08853282241306245

Yi Gui Zhou, Song Kai Li, Yun Xue, Bo Fan, Qiu Ming Gao, Long Wen Zhan, Rui Tang Liu, Yun Fei Li, Rui Long Sun, Yong Zheng Tian

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Abstract

The Diels-Alder reaction, a classical (4+2) cycloaddition process, holds significant standing within the realms of organic synthesis and polymer chemistry, frequently employed in areas such as pharmaceutical production and material science. Recently, hydrogels constructed via Diels-Alder reactions have garnered considerable attention from researchers. This review aims to summarize the advancements in utilizing the Diels-Alder reaction for hydrogel synthesis, exploring its impact on structural design, functionalization, and application domains. Initially, the fundamental principles of the Diels-Alder reaction are introduced alongside an examination of its benefits and characteristics in hydrogel fabrication. Subsequently, applications of Diels-Alder-generated hydrogels in biomedicine, smart responsive materials, drug delivery systems, among other fields, are comprehensively reviewed. Challenges and limitations encountered during hydrogel synthesis using this reaction are also discussed. Finally, prospective research directions and future prospects of Diels-Alder reactions in hydrogel synthesis are contemplated.

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水凝胶合成中的 Diels-Alder 反应：机理和功能方面。

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.