{"title":"Meroterpenoids from <i>Rhododendron racemosum</i> and their anti-inflammatory activities.","authors":"Si-Xuan Liu, Si-Yang Dai, Yong-Fu Lu, Chun-Lin Guo, Chang Li, Yi-Hui Yang, Yue-Hu Pei","doi":"10.1080/10286020.2024.2431813","DOIUrl":null,"url":null,"abstract":"<p><p>Three meroterpenoids, including one new compound, ranhuadujuanine E (<b>1</b>), one new natural product, methyl (<i>E</i>)-3-(3,7-dimethylocta-2,6-dien-1-yl)-2,4-dihydroxy-6-methylbenzoate (<b>2</b>), and one known compound, ranhuadujuanine D (<b>3</b>), along with two known sesquiterpenoids (<b>4</b>-<b>5</b>) were isolated from <i>Rhododendron racemosum</i>. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of C-6' in compound <b>1</b> was assigned by using Snatzke's method. Compounds <b>1</b>-<b>3</b> had inhibitory effects on LPS-induced NO release in RAW264.7 cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3000,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2024.2431813","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Three meroterpenoids, including one new compound, ranhuadujuanine E (1), one new natural product, methyl (E)-3-(3,7-dimethylocta-2,6-dien-1-yl)-2,4-dihydroxy-6-methylbenzoate (2), and one known compound, ranhuadujuanine D (3), along with two known sesquiterpenoids (4-5) were isolated from Rhododendron racemosum. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of C-6' in compound 1 was assigned by using Snatzke's method. Compounds 1-3 had inhibitory effects on LPS-induced NO release in RAW264.7 cells.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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