{"title":"Synthesis, Crystal Structure, and Antibacterial Activity of N-(2-Chlorobenzyl)-3-methylbut-2-enamide","authors":"W. J. Hu, Y. Q. Liu, J. Y. Yu","doi":"10.1134/S1070428024100191","DOIUrl":null,"url":null,"abstract":"<p><i>N</i>-(2-Сhlorobenzyl)-3-methylbut-2-enamide was synthesized, and its structure was determined by single crystal X-ray diffraction and other spectroscopic methods. The compound crystallized in <i>P</i>-1 space group of the triclinic crystal system with the following unit cell parameters: <i>a</i> = 8.8767(5), <i>b</i> = 10.2535(6), <i>c</i> = 13.8768(7) Å; α = 98.608(4)°, β = 103.920(4)°, γ = 98.298(4)°; <i>Z</i> = 4; <i>d</i><sub>calc</sub> = 1.248 g/cm<sup>3</sup>; <i>V</i> = 1190.54(12) Å<sup>3</sup>. Preliminary antibacterial tests showed that <i>N</i>-(2-chlorobenzyl)-3-methylbut-2-enamide exhibited strong antibacterial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> with minimum inhibitory concentration (MIC) values of 0.01 and 0.02 g/mL, respectively. However, this compound has no obvious bacteriostatic effect on <i>Enterobacter aerogenes</i>.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 10","pages":"2020 - 2025"},"PeriodicalIF":0.8000,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070428024100191","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
N-(2-Сhlorobenzyl)-3-methylbut-2-enamide was synthesized, and its structure was determined by single crystal X-ray diffraction and other spectroscopic methods. The compound crystallized in P-1 space group of the triclinic crystal system with the following unit cell parameters: a = 8.8767(5), b = 10.2535(6), c = 13.8768(7) Å; α = 98.608(4)°, β = 103.920(4)°, γ = 98.298(4)°; Z = 4; dcalc = 1.248 g/cm3; V = 1190.54(12) Å3. Preliminary antibacterial tests showed that N-(2-chlorobenzyl)-3-methylbut-2-enamide exhibited strong antibacterial activity against Escherichia coli and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 0.01 and 0.02 g/mL, respectively. However, this compound has no obvious bacteriostatic effect on Enterobacter aerogenes.
期刊介绍：
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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