{"title":"A Convenient Synthesis of 7-Methyladenine","authors":"A. N. Du, Y. L. Feng, Y. H. Yan, T. J. Chen","doi":"10.1134/S1070428024100245","DOIUrl":null,"url":null,"abstract":"<p>7-Methyladenine is a biomarker of DNA damage from exposure to methylating agents. Also, it is a partial agonist for the G protein-coupled receptor in rats. So far, the reported synthetic methods for 7-methyladenine are not convenient enough. We herein report an improved four-step synthesis of 7-methyladenine via cyanation, Raney Ni catalytic reduction, cyclization, and bis(pinacolato)diboron (Bpin)<sub>2</sub> reduction. The advantages of this procedure include the avoidance of precious metal catalysts, simple operation, and good yields.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 10","pages":"2048 - 2051"},"PeriodicalIF":0.8000,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070428024100245","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
7-Methyladenine is a biomarker of DNA damage from exposure to methylating agents. Also, it is a partial agonist for the G protein-coupled receptor in rats. So far, the reported synthetic methods for 7-methyladenine are not convenient enough. We herein report an improved four-step synthesis of 7-methyladenine via cyanation, Raney Ni catalytic reduction, cyclization, and bis(pinacolato)diboron (Bpin)2 reduction. The advantages of this procedure include the avoidance of precious metal catalysts, simple operation, and good yields.
7-甲基腺嘌呤是一种生物标志物，能反映因接触甲基化剂而造成的 DNA 损伤。此外，它还是大鼠 G 蛋白偶联受体的部分激动剂。迄今为止，所报道的 7-甲基腺嘌呤合成方法不够方便。我们在此报告一种经过改进的四步合成 7-甲基腺嘌呤的方法，即通过氰化、Raney Ni 催化还原、环化和双(频哪醇)二硼(Bpin)2 还原。该方法的优点包括避免使用贵金属催化剂、操作简单和收率高。
期刊介绍：
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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