Cover Feature: A CH4-Driven Ion Cloud-Stretched Approach Enables ICP-qMS for Multiplex Single-Cell Analysis (Chem. Eur. J. 71/2024)

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemistry - A European Journal Pub Date : 2024-12-18 DOI:10.1002/chem.202487104

Zhengxian Lv, Xinli Yan, Zhen Liu, Shi Chen, Xiaowen Yan, Limin Yang, Qiuquan Wang

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Abstract

Cells are heterogenous like different human individuals. Labeling cells by using lanthanide (Ln)-tagged macrophage MS2 capsid-conjugated antibody toward the corresponding cell-surface biomarkers, and stretching the ICP-generated ion cloud duration of the Ln-labeled single-cell by using CH₄ in collision-reaction cell (CRC), allowed the acquisition of multi-m/z signals by ICP-quadrupole (q)-MS (ICP-(CH₄-CRC)-qMS). Multiplex analysis of the Ln-labeled single cells by using ICP-(CH₄-CRC)-qMS recovers their intrinsically colorful features. More information can be found in the Research Article by X. Yan, Q. Wang and co-workers (DOI: 10.1002/chem.202402289).

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封面专题：一种以 CH4 为驱动力的离子云拉伸方法使 ICP-qMS 可用于多重单细胞分析（《欧洲化学杂志》71/2024）

细胞就像不同的人类个体一样具有异质性。利用镧系元素（Ln）标记的巨噬细胞MS2衣壳偶联抗体将细胞标记为相应的细胞表面生物标志物，并在碰撞反应细胞（CRC）中利用CH4延长ICP-四极杆(q)-质谱（ICP-(CH4-CRC)- qms）延长ICP-离子云持续时间，从而实现ICP-四极杆(q)-质谱获取多m/z信号。利用ICP-(CH4-CRC)- qms对ln标记的单细胞进行多重分析，恢复其固有的彩色特征。更多信息可以在Yan X.， Q. Wang等人的研究文章中找到（DOI: 10.1002/chem.202402289）。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.