Innenrücktitelbild: Collective Asymmetric Synthesis of Thiosilvatins (Angew. Chem. 51/2024)

Dr. Jian Liu, Robin Ekberg, Dr. Nicolas R. Koning, Prof. Daniel Strand
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Abstract

Thiosilvatins are a class of biologically active dithiodiketopiperazine natural products. In their Research Article (e202412397), Daniel Strand and co-workers describe a first, collective, synthesis of thiosilvatins, introducing methods and tactics to overcome stereochemical issues in dithiodiketopiperazine synthesis. The artwork depicts thiosilvatins emerging from and escaping an abyss of inaccessibility and structural ambiguity.

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Innenrücktitelbild:硫代硅烷的集体不对称合成(Angew.)
硫银苷是一类具有生物活性的二硫代二酮哌嗪类天然产物。在他们的研究文章(e202412397)中,Daniel Strand及其同事首次描述了硫银苷的集体合成,介绍了克服二硫代二酮哌嗪合成中立体化学问题的方法和策略。该作品描绘了硫银从不可接近和结构模糊的深渊中出现并逃离。
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来源期刊
Angewandte Chemie
Angewandte Chemie 化学科学, 有机化学, 有机合成
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