Innenrücktitelbild: Collective Asymmetric Synthesis of Thiosilvatins (Angew. Chem. 51/2024)

Abstract

Thiosilvatins are a class of biologically active dithiodiketopiperazine natural products. In their Research Article (e202412397), Daniel Strand and co-workers describe a first, collective, synthesis of thiosilvatins, introducing methods and tactics to overcome stereochemical issues in dithiodiketopiperazine synthesis. The artwork depicts thiosilvatins emerging from and escaping an abyss of inaccessibility and structural ambiguity.