Front Cover: Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages (EXP2 6/2024)
Baiyan Sui, Tingting Ding, Xingyi Wan, Yuxiao Chen, Xiaodi Zhang, Yuanbo Cui, Jie Pan, Linlin Li, Xin Liu
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Abstract
Liu et al. developed a wireless piezoelectric hydrogel with BaTiO3 nanoparticles, generating piezoelectric potentials to reprogram macrophages towards the M2 phenotype, enhancing osteogenesis in bone marrow stem cells and promoting bone regeneration at load-bearing alveolar sites. This piezoelectric-driven osteoimmunomodulation offers new insights for designing next-generation bioactive materials with combined osteoinductive, immunomodulatory, and piezoelectric properties.
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