Recent Advances in Individualized Clinical Strategies for Polycystic Ovary Syndrome: Evidence From Clinical Trials and Emerging Pharmacotherapies

IF 3.2 4区医学 Q2 PHARMACOLOGY & PHARMACY Clinical therapeutics Pub Date : 2025-02-01 DOI:10.1016/j.clinthera.2024.11.015

Murali Krishna Moka PhD , Damal Kandadai Sriram FRCP , Melvin George DM

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Abstract

Purpose

Clinical trials are advancing the treatment of polycystic ovary syndrome (PCOS), an endocrine disorder affecting 8-13% of women. Lifestyle interventions, including nutritional plans, physical activity, and stress management, can improve reproductive hormones and metabolic health. Novel pharmacotherapies targeting hormonal, metabolic, and reproductive abnormalities are being explored for individualized treatment. Combination therapies and lifestyle interventions like acupuncture, high-intensity interval training, and vitamin D3 supplementation are also being explored.

Methods

We conducted a narrative review by searching English-language studies across electronic databases such as PubMed, Science direct, and Google Scholar for articles related to the topics of PCOS and novel drug therapies such as metformin, LIK-066, elagolix, saxenda, exenatide, clomiphene, letrozole, and other diagnostic interventions. Our review excluded preclinical studies and articles not in english.

Findings

In addition to pharmacological treatments, lifestyle interventions such as Tung's acupuncture, high-intensity interval training (HIIT), and vitamin D3 supplementation have proven effective in managing symptoms of PCOS and enhancing overall health outcomes. These interventions offer a complementary approach to traditional medical therapies, emphasizing the importance of integrating lifestyle modifications into the treatment plan for women with PCOS.

Implications

This comprehensive approach underscores the importance of tailored treatments in optimizing clinical outcomes and quality of life for women with PCOS. The aim of this review is to highlight recent advancements in the treatment of PCOS through clinical trials and emerging pharmacotherapies, emphasizing the need for individualized and multifaceted treatment approaches.

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多囊卵巢综合征个体化临床治疗策略的最新进展：来自临床试验和新兴药物治疗的证据。

目的：临床试验正在推进多囊卵巢综合征（PCOS）的治疗，这是一种影响8-13%女性的内分泌疾病。生活方式干预，包括营养计划、体育活动和压力管理，可以改善生殖激素和代谢健康。针对激素、代谢和生殖异常的新型药物治疗正在探索个体化治疗。联合疗法和生活方式干预，如针灸、高强度间歇训练和补充维生素D3也在探索中。方法：我们通过在PubMed、Science direct和谷歌Scholar等电子数据库中搜索与PCOS和新型药物治疗（如二甲双胍、lik066、elagolix、saxenda、艾塞那肽、克罗米芬、来曲唑和其他诊断干预措施）主题相关的英文研究进行了叙事性回顾。我们的综述排除了临床前研究和非英文文章。研究结果：除了药物治疗外，生活方式干预，如董氏针灸、高强度间歇训练（HIIT）和维生素D3补充，已被证明对控制多囊卵巢综合征症状和提高整体健康结果有效。这些干预措施为传统医学治疗提供了一种补充方法，强调了将生活方式改变纳入多囊卵巢综合征妇女治疗计划的重要性。意义：这种综合方法强调了定制治疗在优化PCOS女性临床结果和生活质量方面的重要性。本综述的目的是通过临床试验和新兴药物疗法来强调多囊卵巢综合征治疗的最新进展，强调个性化和多方面治疗方法的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical therapeutics 医学-药学

CiteScore

6.00

自引率

3.10%

发文量

154

审稿时长

9 weeks

期刊介绍： Clinical Therapeutics provides peer-reviewed, rapid publication of recent developments in drug and other therapies as well as in diagnostics, pharmacoeconomics, health policy, treatment outcomes, and innovations in drug and biologics research. In addition Clinical Therapeutics features updates on specific topics collated by expert Topic Editors. Clinical Therapeutics is read by a large international audience of scientists and clinicians in a variety of research, academic, and clinical practice settings. Articles are indexed by all major biomedical abstracting databases.