An improved ultrasound-assisted synthesis of phenytoin suitable for undergraduate education.

IF 8.7 1区 化学 Q1 ACOUSTICS Ultrasonics Sonochemistry Pub Date : 2025-01-01 Epub Date: 2024-12-19 DOI:10.1016/j.ultsonch.2024.107207
Baowei Yang, Xiandong Zhai, Runzhe Mei, Pu Wang, Yicheng Mei
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引用次数: 0

Abstract

A convenient and efficient method for undergraduate student experiments involves the one-pot synthesis of phenytoin from benzoin. This method utilized ultrasonic irradiation in the presence of basic catalyst at room temperature and atmospheric pressure, resulting in shortened reaction times, good yields, and excellent reproducibility. By employing a low-cost ultrasonic cleaner for ultrasonic irradiation in student experiments, the need for expensive equipment investment during the teaching process can be minimized. Consequently, this approach is suitable for widespread promotion and application in undergraduate education.

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超声辅助苯妥英合成的一种改进方法。
以安息香为原料,一锅法合成苯妥英是一种方便、高效的本科生实验方法。该方法利用常温常压下碱性催化剂存在下的超声波辐照,缩短了反应时间,收率高,重现性好。在学生实验中采用低成本的超声波清洗机进行超声波照射,可以最大限度地减少教学过程中对昂贵设备的投资。因此,这种方法适合在本科教育中广泛推广和应用。
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阿拉丁
ethyl acetate
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Dimethyl sulfoxide
来源期刊
Ultrasonics Sonochemistry
Ultrasonics Sonochemistry 化学-化学综合
CiteScore
15.80
自引率
11.90%
发文量
361
审稿时长
59 days
期刊介绍: Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels. Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.
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