Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy for Non-Small Cell Lung Cancer Using Varian Ethos Therapy System.

IF 2.8 4区医学 Q2 ONCOLOGY Current oncology Pub Date : 2024-12-01 DOI:10.3390/curroncol31120562

Vanda Leipold, Blanka Jakšić, Asmir Avdičević, Domagoj Kosmina, Hrvoje Kaučić, Ivana Alerić, Karla Schwarz, Mihaela Mlinarić, Giovanni Ursi, Adlan Čehobašić, Dragan Schwarz

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Abstract

We present a patient treated with personalized ultra-fractionated stereotactic adaptive radiotherapy (PULSAR) for non-small cell lung cancer (NSCLC) using the adaptive Varian Ethos™ system equipped with the novel HyperSight imaging platform. Three pulses of 12 Gy were separated by a pause of four weeks during which the tumor was given enough time to respond to treatment. Only initial planning computed tomography (CT) was acquired on a CT simulator (Siemens Somatom Definition Edge), whereas other pulses were adapted using online cone beam computed tomography (CBCT) images (iCBCT Acuros reconstruction) acquired while the patient was lying on the treatment couch and delivered immediately. Significant tumor reduction was achieved between pulses, resulting in improved organs-at-risk sparing. In addition, the on-couch plan optimization based on CBCT greatly reduced the patient's stay at the clinic and the duration of treatment preparation.

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使用瓦里安Ethos治疗系统治疗非小细胞肺癌的个性化超分割立体定向放射治疗。

我们介绍了一名患者，使用配备新型HyperSight成像平台的自适应Varian Ethos™系统，对非小细胞肺癌（NSCLC）进行个性化超分割立体定向自适应放疗（PULSAR）治疗。三个12 Gy的脉冲间隔四周，在此期间肿瘤有足够的时间对治疗作出反应。仅在CT模拟器（Siemens Somatom Definition Edge）上获得初始计划计算机断层扫描（CT），而其他脉冲则使用在线锥形束计算机断层扫描（CBCT）图像（iCBCT Acuros重建）进行调整，这些图像是在患者躺在治疗台上获得的，并立即交付。在两次脉冲之间实现了显著的肿瘤减少，从而改善了危险器官的保留。此外，基于CBCT的卧床计划优化大大减少了患者在诊所的停留时间和治疗准备时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current oncology ONCOLOGY-

CiteScore

3.30

自引率

7.70%

发文量

664

审稿时长

1 months

期刊介绍： Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease. We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.