Updates on the Pathogenesis of Canine Atopic Dermatitis and Feline Atopic Skin Syndrome: Part 2, the Skin Barrier, the Microbiome, and Immune System Dysfunction

IF 2 3区 农林科学 Q2 VETERINARY SCIENCES Veterinary Clinics of North America-Small Animal Practice Pub Date : 2025-03-01 Epub Date: 2024-12-27 DOI:10.1016/j.cvsm.2024.11.002
Christina M. Gentry DVM
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犬特应性皮炎和猫特应性皮肤综合征发病机制的最新进展:第2部分:皮肤屏障、微生物群和免疫系统功能障碍。
脂质层和细胞间角质细胞连接的改变可导致过敏原通过皮肤表面的渗透增加。正常的皮肤微生物群使机会致病菌假中葡萄球菌的水平保持在较低水平,但过敏性炎症导致假中葡萄球菌的多样性降低和增加。角质形成细胞通过细胞因子信号传导发出最初的过敏原警报,并促进t -辅助2 (Th-2)炎症。Th-2细胞因子产物IL-4、IL-13和IL-31在急性过敏性炎症反应中升高。t -辅助性1、t -辅助性17和t调节细胞的反应改变在急性和慢性过敏性炎症中都起作用。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
123
审稿时长
18-36 weeks
期刊介绍: Veterinary Clinics of North America: Small Animal Practice offers you the most current information on the treatment of small animals such as cats and dogs, updates you on the latest advances, and provides a sound basis for choosing treatment options. Published bi-monthly—in January, March, May, July, September, November—each issue focuses on a single topic in small animal practice, including endocrinology, fluids and electrolytes, gastroenterology, infectious diseases, neurology, oncology, urology, respiratory issues , surgical information, small animal behavior, laboratory medicine, imaging methods, and nutrition.
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