Mengjing Cong, Yinyan Li, Yanqin Li, Xiangliu Chen, Xiaoyan Pang, Yan Yan, Xinpeng Tian, Yonghong Liu, Jie Yang, Junfeng Wang
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引用次数: 0
Abstract
Spirochrains A–D, four undescribed spirocyclic amides, were obtained from an Antarctic fungus, Aspergillus ochraceopetaliformis SCSIO 05702. Their structures were elucidated through spectroscopic analysis and quantum calculations. Spirochrains A–D possess a rarely reported cage-like 5/6/5 fused spirocyclic amide scaffold. Spirochrain B exerted antiviral effects by targeting the viral entry phase and inhibiting viral adsorption. Noteworthily, surface plasmon resonance (SPR) revealed strong binding affinity of 2 to RSV-G protein with a KD value of 7.95 nM.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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