Vaping mice

IF 3.9 3区 农林科学 Q1 VETERINARY SCIENCES Lab Animal Pub Date : 2025-01-03 DOI:10.1038/s41684-024-01496-y
Alexandra Le Bras
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vap的老鼠
近年来,青少年使用电子烟的人数迅速增加,引发了人们对电子烟对大脑发育潜在长期影响的担忧。在一项新的研究中,亨德森及其同事在提取小鼠大脑以评估神经元功能之前,使用电子烟自我给药(EVSA)试验来比较雄性和雌性成年和青少年C57BL/6J小鼠与电子烟相关的尼古丁强化。结果表明,青春期暴露的雄性比成年暴露的雄性表现出更多的强化相关行为,而青春期暴露的雌性和成年暴露的雌性表现出相似的强化相关行为。该研究还发现了青春期暴露于尼古丁蒸汽自我管理的小鼠的独特神经生物学变化,包括内侧前额叶皮层(mPFC)锥体神经元的内在兴奋性增加,伏隔核核心(NAcc)多巴胺释放增强以及乙酰胆碱受体动力学的变化。青少年和成人对尼古丁的不同反应强调了在研究尼古丁暴露对身体和大脑健康的影响时考虑发育阶段的重要性。原始文献:Henderson, B.J.等。Commun。生物学报7,1553 (2024)
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来源期刊
Lab Animal
Lab Animal 农林科学-兽医学
CiteScore
0.60
自引率
2.90%
发文量
181
审稿时长
>36 weeks
期刊介绍: LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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