{"title":"Synthesis of 6H-Benzo[c]chromene Scaffolds: A Synthetic Strategy of Pd-Catalyzed Annulation Followed by Aerial Oxidation","authors":"Kangkana Chutia, Priyanka Saikia, Dhiraj Dutta, Babulal Das, Pranjal Gogoi","doi":"10.1021/acs.joc.4c02780","DOIUrl":null,"url":null,"abstract":"A synthetic strategy of a palladium-catalyzed cascade annulation reaction followed by aerial oxidation was designed to construct 6<i>H</i>-benzo[c]chromene scaffolds. Various 6<i>H</i>-benzo[c]chromenes were synthesized under mild reaction conditions using easily accessible <i>p</i>-QMs and commercially available <i>o</i>-hydroxyarylboronic acids. One of the synthesized chromenes has been ambiguously confirmed by single-crystal XRD analysis. Interestingly, our synthesized 6<i>H</i>-benzo[c]chromenes could be easily transformed into valuable 6<i>H</i>-benzo[c]chromen-6-ones via aerial oxidation.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"203 1","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Organic Chemistry","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1021/acs.joc.4c02780","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A synthetic strategy of a palladium-catalyzed cascade annulation reaction followed by aerial oxidation was designed to construct 6H-benzo[c]chromene scaffolds. Various 6H-benzo[c]chromenes were synthesized under mild reaction conditions using easily accessible p-QMs and commercially available o-hydroxyarylboronic acids. One of the synthesized chromenes has been ambiguously confirmed by single-crystal XRD analysis. Interestingly, our synthesized 6H-benzo[c]chromenes could be easily transformed into valuable 6H-benzo[c]chromen-6-ones via aerial oxidation.
期刊介绍：
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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