Pre-stroke patient characteristics that influence skeletal muscle quality: A cross-sectional study.

IF 2.4 4区医学 Q3 GERIATRICS & GERONTOLOGY Geriatrics & Gerontology International Pub Date : 2025-01-02 DOI:10.1111/ggi.15060

Keisuke Honma, Yosuke Honda, Masahiro Nagase, Yuta Nakao, Koichiro Sota, Naoki Sasanuma, Masataka Igeta, Yuki Uchiyama, Kazuhisa Domen

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Abstract

Aim: One of the parameters that is measurable using bioelectrical impedance is the phase angle (PhA), which is an indicator of skeletal muscle quality. The PhA reflects cellular health and nutritional status and is an important parameter for monitoring recovery after stroke. However, the factors affecting skeletal muscle quality remain unclear. Therefore, this study aimed to identify the factors associated with skeletal muscle quality in patients with acute stroke.

Methods: A total of 505 consecutively hospitalized patients with acute stroke were included in this study. The primary outcome was the PhA measured by bioelectrical impedance analysis, which evaluates muscle quality. Multiple regression analysis was performed to identify the factors affecting PhA.

Results: The mean age of the participants was 75.1 years, and 44% were female. The median National Institutes of Health Stroke Scale (NIHSS) score upon admission was 4, and the mean length of stay was 18 days. The mean PhA for skeletal muscle quality was 4.9° in males and 3.9° in females. Multiple regression analysis showed that age, sex, pre-stroke modified Rankin Scale (pre-mRS), Geriatric Nutritional Risk Index, type 2 diabetes mellitus, atrial fibrillation, and chronic kidney disease had independent effects on PhA (R² = 0.575; P = 0.001). Age, pre-mRS, NIHSS, dementia, and PhA independently associated with functional independence measure at discharge (R² = 0.657; P = 0.001).

Conclusions: This study identified determinants contributing to the deterioration of muscle quality upon admission in acute stroke patients. Further investigation is needed to ascertain whether modulation of these factors improves muscle quality. Geriatr Gerontol Int 2025; ••: ••-••.

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影响骨骼肌质量的中风前患者特征：一项横断面研究。

目的：相位角（PhA）是可通过生物电阻抗测量的参数之一，它是骨骼肌质量的指标。PhA 反映了细胞健康和营养状况，是监测中风后恢复情况的重要参数。然而，影响骨骼肌质量的因素仍不清楚。因此，本研究旨在确定急性脑卒中患者骨骼肌质量的相关因素：本研究共纳入 505 名连续住院的急性脑卒中患者。主要结果是通过生物电阻抗分析测量的 PhA，该指标可评估肌肉质量。研究人员进行了多元回归分析，以确定影响 PhA 的因素：参与者的平均年龄为 75.1 岁，44% 为女性。入院时美国国立卫生研究院卒中量表（NIHSS）评分中位数为 4 分，平均住院时间为 18 天。男性骨骼肌质量的平均 PhA 为 4.9°，女性为 3.9°。多元回归分析表明，年龄、性别、卒中前改良Rankin量表（pre-mRS）、老年营养风险指数、2型糖尿病、心房颤动和慢性肾病对PhA有独立影响（R2 = 0.575; P = 0.001）。年龄、mRS 前值、NIHSS、痴呆和 PhA 与出院时的功能独立性测量值独立相关（R2 = 0.657；P = 0.001）：本研究确定了急性卒中患者入院时肌肉质量恶化的决定因素。结论：本研究发现了导致急性脑卒中患者入院时肌肉质量恶化的决定因素，需要进一步研究以确定调节这些因素是否能改善肌肉质量。Geriatr Gerontol Int 2025; --：-----.

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来源期刊

Geriatrics & Gerontology International 医学-老年医学

CiteScore

5.50

自引率

6.10%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Geriatrics & Gerontology International is the official Journal of the Japan Geriatrics Society, reflecting the growing importance of the subject area in developed economies and their particular significance to a country like Japan with a large aging population. Geriatrics & Gerontology International is now an international publication with contributions from around the world and published four times per year.