The relationship between discordant birth weight in twin pairs and the development of retinopathy of prematurity.

IF 1.2 4区医学 Q3 OPHTHALMOLOGY Journal of Aapos Pub Date : 2024-12-31 DOI:10.1016/j.jaapos.2024.104095

Mackenzie A Campbell, Nathan C Grove, Robert S McDuffie, Emily A Auer, Arden J McReynolds, Emily A McCourt, Erica M Wymore, Naresh Mandava, Brandie D Wagner, Marc T Mathias, Scott C N Oliver, Jennifer L Jung, Anne M Lynch

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Abstract

The association of low birth weight and development of retinopathy of prematurity (ROP) is well established for singletons; however, the association of birth weight and ROP in twins of discordant weight is understudied. Using an ROP registry, we investigated whether smaller twins were at greater risk for developing any stage ROP (stage 1 or greater in either eye) compared with their larger siblings, after adjusting for birth weight and gestational age. Discordance was defined as a birth weight difference of >25%. In a cohort of 2,083 infants (2006-2021), 36 discordant twin pairs were identified. The smaller twin had an increased odds of developing any ROP (OR = 2.7; 95% CI, 1.3-5.9; P = 0.01) compared with the larger sibling. This relationship was no longer significant following adjustment for gestational age and birth weight (adjusted OR = 0.92; CI, 0.11-7.43; P = 0.94). The results suggest that although the smaller twins in discordant pairs are at an increased risk of any stage ROP, this risk is driven by low birth weight conditional on gestational age.

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双胞胎出生体重不一致与早产儿视网膜病变的关系。

低出生体重与早产儿视网膜病变（ROP）发展的关系在单胎中得到了很好的证实；然而，体重不一致的双胞胎的出生体重和ROP的关系还没有得到充分的研究。通过ROP登记，我们调查了在调整出生体重和胎龄后，与较大的兄弟姐妹相比，较小的双胞胎是否有更大的风险发生任何阶段的ROP（双眼均为1期或更高）。不一致被定义为出生体重差bb0 25%。在2006-2021年的2083名婴儿队列中，发现了36对不一致的双胞胎。较小的双胞胎发生任何ROP的几率增加(OR = 2.7；95% ci, 1.3-5.9；P = 0.01)。在调整胎龄和出生体重后，这种关系不再显著(调整OR = 0.92；CI, 0.11 - -7.43;P = 0.94)。结果表明，尽管不一致的双胞胎中较小的双胞胎在任何阶段ROP的风险都增加，但这种风险是由胎龄条件下的低出生体重驱动的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Aapos 医学-小儿科

CiteScore

2.40

自引率

12.50%

发文量

159

审稿时长

55 days

期刊介绍： Journal of AAPOS presents expert information on children''s eye diseases and on strabismus as it affects all age groups. Major articles by leading experts in the field cover clinical and investigative studies, treatments, case reports, surgical techniques, descriptions of instrumentation, current concept reviews, and new diagnostic techniques. The Journal is the official publication of the American Association for Pediatric Ophthalmology and Strabismus.