Effect of atorvastatin gel in non-surgical treatment of peri-implant mucositis: A randomized controlled clinical trial.

Journal of advanced periodontology & implant dentistry Pub Date : 2024-09-11 eCollection Date: 2024-01-01 DOI:10.34172/japid.2024.017

Azin Khorramdel, Katayoun Mogharrab Alile, Yousef Kananizadeh, Seyed Amin Mousavi, Fatima Molavi

{"title":"Effect of atorvastatin gel in non-surgical treatment of peri-implant mucositis: A randomized controlled clinical trial.","authors":"Azin Khorramdel, Katayoun Mogharrab Alile, Yousef Kananizadeh, Seyed Amin Mousavi, Fatima Molavi","doi":"10.34172/japid.2024.017","DOIUrl":null,"url":null,"abstract":"Background: Peri-implant diseases, such as peri-implant mucositis and peri-implantitis, are inflammatory conditions caused by biofilms that can lead to the loss of surrounding soft tissues and bone. The most effective treatment involves non-surgical mechanical debridement to remove plaque, but other treatment modalities have shown limited success. This study investigated the anti-inflammatory and immunomodulatory effects of atorvastatin (ATV) gel as an additional treatment for peri-implant mucositis.Methods: In this double-masked, randomized clinical trial, 49 patients with peri-implant mucositis were randomly divided into two treatment groups: mechanical debridement (MD)+placebo or MD+ATV gel. At baseline, 1 month, and 3 months after the intervention, periodontal parameters, including probing depth (PD), bleeding on probing (BOP), clinical attachment level (CAL), and pain on probing (POP), were measured. Data were analyzed using independent t-test and paired t-test.Results: Statistically significant improvements in CAL and POP were observed from baseline to each time point throughout the study period (P≤0.001). PD and BOP were statistically significant 1 month and 3 months after the intervention, respectively (P<0.05).Conclusion: The clinical parameters associated with peri-implant mucosal inflammation further improved when ATV gel was used with MD.","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"16 2","pages":"116-122"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699258/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of advanced periodontology & implant dentistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/japid.2024.017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Peri-implant diseases, such as peri-implant mucositis and peri-implantitis, are inflammatory conditions caused by biofilms that can lead to the loss of surrounding soft tissues and bone. The most effective treatment involves non-surgical mechanical debridement to remove plaque, but other treatment modalities have shown limited success. This study investigated the anti-inflammatory and immunomodulatory effects of atorvastatin (ATV) gel as an additional treatment for peri-implant mucositis.

Methods: In this double-masked, randomized clinical trial, 49 patients with peri-implant mucositis were randomly divided into two treatment groups: mechanical debridement (MD)+placebo or MD+ATV gel. At baseline, 1 month, and 3 months after the intervention, periodontal parameters, including probing depth (PD), bleeding on probing (BOP), clinical attachment level (CAL), and pain on probing (POP), were measured. Data were analyzed using independent t-test and paired t-test.

Results: Statistically significant improvements in CAL and POP were observed from baseline to each time point throughout the study period (P≤0.001). PD and BOP were statistically significant 1 month and 3 months after the intervention, respectively (P<0.05).

Conclusion: The clinical parameters associated with peri-implant mucosal inflammation further improved when ATV gel was used with MD.

查看原文