Synthesis and Characterization of Heterocyclic Ligand and Its Metal Complexes

Abstract

A ligand has been synthesized from 1-(1-methyl-5-(tosylamino)-1H-1,2,3-triazol-4-yl)ethanone and dimethylpyrimidyl hydrazone, and its copper(II), nickel(II), and zinc(II) complexes have been produced and analyzed. The X-ray diffraction analysis shows that the zinc(II) combination with the N₃O donor ligand environment has the form of a tetragonal pyramid. The chelate core of the copper(II) complex is structurally identical, as shown by X-ray data. The coordination core of the nickel(II) complex is an octahedron, which is completed by the solvent molecule. Pharmacological evidence of antibacterial activity was obtained for all the substances. The synthetic compounds have been studied and compared to existing antibiotics like chloramphenicol and amphotericin B for their ability to kill bacteria and fungi, respectively.