Skeletal Muscle Stem Cells and the Microenvironment Regulation in Sarcopenia:A Review.

Q4 Medicine 中国医学科学院学报 Pub Date : 2024-12-01 DOI:10.3881/j.issn.1000-503X.16114

Tian Gao, Yong Zhang, Dan Zhang, Ping Zeng

{"title":"Skeletal Muscle Stem Cells and the Microenvironment Regulation in Sarcopenia:A Review.","authors":"Tian Gao, Yong Zhang, Dan Zhang, Ping Zeng","doi":"10.3881/j.issn.1000-503X.16114","DOIUrl":null,"url":null,"abstract":"<p><p>Sarcopenia is an age-related degenerative skeletal muscle disorder characterized by the loss of skeletal muscle mass and function during aging.Sarcopenia can impair the elderly's ability to perform daily activities and is associated with high risks of falls,fractures,and hospitalization.It seriously affects the quality of life of the elderly and becomes one of the major health problems in the aging society.Skeletal muscle stem cells,also known as muscle satellite cells,play a key role in supporting muscle regeneration and homeostasis maintenance.Studies have suggested that muscle satellite cell functions are tightly regulated by microenvironment signals in the skeletal muscle.Of note,skeletal muscle fibers,serving as an immediate niche of muscle satellite cells,regulate their activation,proliferation,and self-renewal.This article reviews the research progress in the regulatory roles of skeletal muscle stem cells and their microenvironment in sarcopenia during aging,providing theoretical support for potential treatment of sarcopenia via modifying skeletal muscle microenvironment and regulating muscle satellite cell functions.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"46 6","pages":"958-964"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国医学科学院学报","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.3881/j.issn.1000-503X.16114","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Sarcopenia is an age-related degenerative skeletal muscle disorder characterized by the loss of skeletal muscle mass and function during aging.Sarcopenia can impair the elderly's ability to perform daily activities and is associated with high risks of falls,fractures,and hospitalization.It seriously affects the quality of life of the elderly and becomes one of the major health problems in the aging society.Skeletal muscle stem cells,also known as muscle satellite cells,play a key role in supporting muscle regeneration and homeostasis maintenance.Studies have suggested that muscle satellite cell functions are tightly regulated by microenvironment signals in the skeletal muscle.Of note,skeletal muscle fibers,serving as an immediate niche of muscle satellite cells,regulate their activation,proliferation,and self-renewal.This article reviews the research progress in the regulatory roles of skeletal muscle stem cells and their microenvironment in sarcopenia during aging,providing theoretical support for potential treatment of sarcopenia via modifying skeletal muscle microenvironment and regulating muscle satellite cell functions.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

骨骼肌干细胞与肌减少症的微环境调控：综述。

骨骼肌减少症是一种与年龄相关的退行性骨骼肌疾病，其特征是在衰老过程中骨骼肌质量和功能的丧失。骨骼肌减少症会损害老年人进行日常活动的能力，并与跌倒、骨折和住院的高风险相关。严重影响老年人的生活质量，成为老龄化社会的主要健康问题之一。骨骼肌干细胞，也被称为肌肉卫星细胞，在支持肌肉再生和维持体内平衡方面起着关键作用。研究表明，肌肉卫星细胞的功能受到骨骼肌微环境信号的严格调控。值得注意的是，骨骼肌纤维作为肌肉卫星细胞的直接生态位，调节其激活、增殖和自我更新。本文综述了衰老过程中骨骼肌干细胞及其微环境在骨骼肌减少症中的调控作用的研究进展，为通过改变骨骼肌微环境和调节肌肉卫星细胞功能治疗骨骼肌减少症提供理论支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

中国医学科学院学报 Medicine-Medicine (all)

CiteScore

0.60

自引率

0.00%

发文量

6813

期刊介绍： Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College. The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].