Predictive value of abnormal expression of MPHOSPH9 in reintervention after high intensity focused ultrasound treatment of uterine fibroids

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY Journal of Obstetrics and Gynaecology Research Pub Date : 2025-01-08 DOI:10.1111/jog.16205

Jing Wang, Yingjie Xie, Chaoqiang Zeng, Lin Nie, Yang Yang

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引用次数: 0

Abstract

Aims

Aberrantly expressed MPHOSPH9 has been reported to be associated with poor prognosis in many diseases. Previous study indicates that MPHOSPH9 is abnormally expressed in patients with uterine fibroids (UFs). This study focused on the possible prognostic value of MPHOSPH9 in UFs patients after high intensity focused ultrasound (HIFU) treatment.

Methods

A total of 455 UFs patients participated in the study, including 95 patients who needed reintervention (Reintervention group) and 360 patients who did not need reintervention (Non-reintervention group) after HIFU treatment. They volunteered blood samples before HIFU treatment. The relative expression of MPHOSPH9 was assessed by qRT-PCR. Cox regression analysis was performed to assess the prognostic value of MPHOSPH9 and risk factors of postoperative reintervention.

Results

The expression of MPHOSPH9 was markedly elevated in Reintervention, compared to that of the Non-reintervention group (p < 0.001). Five-year follow-up results showed that among these postoperative patients, 95 patients required reintervention and the reintervention time mainly occurred during 10–40 months after surgery. The Cox regression analysis demonstrated that UFs size (hazard ratio = 2.769, 95% confidence interval: 1.366–5.610) and the high MPHOSPH9 expression level (hazard ratio = 3.160, 95% confidence interval: 1.506–6.630) were independent risk factors for postoperative reintervention.

Conclusions

The enhanced MPHOSPH9 was a potential candidate for predicting postoperative reintervention in UFs patients.

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MPHOSPH9异常表达对子宫肌瘤高强度聚焦超声治疗后再干预的预测价值。

目的：在许多疾病中，异常表达的MPHOSPH9与不良预后相关。既往研究表明MPHOSPH9在子宫肌瘤（UFs）患者中表达异常。本研究的重点是MPHOSPH9在UFs患者接受高强度聚焦超声（HIFU）治疗后可能的预后价值。方法：共455例UFs患者参与研究，其中HIFU治疗后需要再干预的患者95例（再干预组），不需要再干预的患者360例（非再干预组）。他们在HIFU治疗前自愿提供血样。采用qRT-PCR检测MPHOSPH9的相对表达量。采用Cox回归分析评价MPHOSPH9的预后价值及术后再干预的危险因素。结果：与非再干预组相比，再干预组MPHOSPH9的表达明显升高(p)。结论：MPHOSPH9的表达增强是预测UFs患者术后再干预的潜在候选者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.