{"title":"Antemortem and Postmortem Diagnosis of <i>Encephalitozoon cuniculi</i> in a Pet Rabbit (<i>Oryctolagus cuniculus</i>)-A Case Report.","authors":"Anca-Alexandra Doboși, Anamaria Ioana Paștiu, Lucia-Victoria Bel, Romelia Pop, Alexandru-Flaviu Tăbăran, Dana Liana Pusta","doi":"10.3390/pathogens13121122","DOIUrl":null,"url":null,"abstract":"<p><p><i>Encephalitozoon</i> cuniculi infection in rabbits represents a true challenge in both diagnosis and treatment of the disease. This study aims to describe and analyze all methods of identifying the presence of the microsporidian in a rabbit through antemortem and postmortem methods. The patient manifested clinical signs of vestibular disease and mild renal symptoms with no significant improvement under treatment, which finally led to euthanasia. Serological and molecular tests confirmed positivity for <i>E. cuniculi</i> in serum and urine, feces, brain, kidney and urinary bladder, respectively. Histopathological findings showed suggestive inflammatory lesions of encephalitis and nephritis and no changes in the eye globe and liver, but with no identification of microsporidian spores. This is the first complete case report of <i>E. cuniculi</i> in a rabbit in Romania, as well as the first report of urinary bladder molecular testing with a positive result, which facilitates for further diagnosis exploration for rabbits.</p>","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":"13 12","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676482/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathogens","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/pathogens13121122","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Encephalitozoon cuniculi infection in rabbits represents a true challenge in both diagnosis and treatment of the disease. This study aims to describe and analyze all methods of identifying the presence of the microsporidian in a rabbit through antemortem and postmortem methods. The patient manifested clinical signs of vestibular disease and mild renal symptoms with no significant improvement under treatment, which finally led to euthanasia. Serological and molecular tests confirmed positivity for E. cuniculi in serum and urine, feces, brain, kidney and urinary bladder, respectively. Histopathological findings showed suggestive inflammatory lesions of encephalitis and nephritis and no changes in the eye globe and liver, but with no identification of microsporidian spores. This is the first complete case report of E. cuniculi in a rabbit in Romania, as well as the first report of urinary bladder molecular testing with a positive result, which facilitates for further diagnosis exploration for rabbits.
期刊介绍：
Pathogens (ISSN 2076-0817) publishes reviews, regular research papers and short notes on all aspects of pathogens and pathogen-host interactions. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodical details must be provided for research articles.
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