Real-World Status in the Treatment of Latent Tuberculosis Infection in People Living with HIV in Korea.

IF 2.8 Q2 INFECTIOUS DISEASES Infection and Chemotherapy Pub Date : 2024-12-01 DOI:10.3947/ic.2024.0126
Hyun-Ha Chang, Hyun-Ju Nam, Hyun Sook Kim, Kyung-Hwa Park, Sohyun Bae, Yoonjung Kim, Shin-Woo Kim, Sook In Jung
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Abstract

This retrospective study analyzed medical records of 1,392 people living with HIV (PLWH) diagnosed with latent tuberculosis infection (LTBI) at two provincial central hospitals from 2011 to 2022. LTBI was diagnosed in 152 patients (10.9%) patients aged ≥18 years. Among the 113 patients who initiated treatment, 96 (85.0%) completed isoniazid therapy, while 17 (15.0%) discontinued due to patient refusal, liver function test abnormalities, and other reasons. During a mean follow-up period of 55.0±31.0 months, two cases of active tuberculosis were reported in both the treatment non-completion group (3.6%) and the completion group (2.1%). This study provides recent real-world insights into LTBI treatment among PLWH in Korea.

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韩国HIV感染者潜伏性结核感染的治疗现状
本回顾性研究分析了2011年至2022年在两家省级中心医院诊断为潜伏性结核感染(LTBI)的1392名HIV感染者(PLWH)的医疗记录。年龄≥18岁的152例(10.9%)患者被诊断为LTBI。113例开始治疗的患者中,96例(85.0%)完成异烟肼治疗,17例(15.0%)因患者拒绝、肝功能检查异常等原因停止治疗。在平均随访55.0±31.0个月期间,治疗未完成组(3.6%)和完成组(2.1%)均报告2例活动性结核病。这项研究为韩国PLWH的LTBI治疗提供了最新的现实见解。
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来源期刊
Infection and Chemotherapy
Infection and Chemotherapy INFECTIOUS DISEASES-
CiteScore
6.60
自引率
11.90%
发文量
71
审稿时长
22 weeks
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