{"title":"Terpenes from <i>Platycladus orientalis</i> and the evaluation of their potential anti-inflammatory activity.","authors":"Yi-Fan Xie, Song-Xue Yang, Xue-Wen Wu, Bo Li, Si-Chen Song, Qiong Wei, Xing-Jie Zhang, Xiao-Li Li, Wei-Lie Xiao","doi":"10.1080/14786419.2024.2448209","DOIUrl":null,"url":null,"abstract":"<p><p>Two undescribed compounds, including one monoterpene (<b>1</b>) and one sesquiterpene (<b>2</b>), together with eleven known compounds were isolated from <i>Platycladus orientalis</i>. The structures of the isolated compounds were determined by comprehensive spectroscopic analysis; the absolute configurations of these compounds were determined by ECD calculation. Some of the compounds were tested for anti-inflammatory activity. The results showed that compounds <b>5-6</b>, <b>9</b> and <b>12</b> exhibited NLRP3-inflammasome inhibitory activity.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6000,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2448209","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Two undescribed compounds, including one monoterpene (1) and one sesquiterpene (2), together with eleven known compounds were isolated from Platycladus orientalis. The structures of the isolated compounds were determined by comprehensive spectroscopic analysis; the absolute configurations of these compounds were determined by ECD calculation. Some of the compounds were tested for anti-inflammatory activity. The results showed that compounds 5-6, 9 and 12 exhibited NLRP3-inflammasome inhibitory activity.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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