Shenqi injection plus probiotics improves nutritional status in patients with gastric cancer after partial gastrectomy.

IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pakistan journal of pharmaceutical sciences Pub Date : 2024-11-01
Yafeng Liu, Mingke Jia
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Abstract

In recent years, the incidence of gastric cancer (GC) has been on the rise, surgical procedures usually require the removal of part of gastric tissue connected with the tumor lesion, which leads to poor postoperative health and adverse prognosis in patients. Probiotics, as an active microorganism, play an important role in improving gastrointestinal function and enhancing immunity. In this study, we randomized 135 GC patients into a control group, a probiotic group and a combination group. All the study subjects were treated with radical GC resection in our hospital. Postoperatively, the control group was given routine treatment, the probiotic group received routine treatment + probiotics and the combined group was given routine treatment+ probiotics +Shenqi injection. Through research, we found that after the use of probiotics, the postoperative rehabilitation process of GC patients was significantly shortened compared to patients treated with conventional enteral nutrition suspension, the immune function and nutritional status were validly improved and the prognostic survival rate was increased. In addition, the CD4+, ALB, HGB, PA and TP of patients in the combination group were higher than those in the probiotic group (P<0.05), while CD4+/CD8+ were lower than those in the probiotic group (P<0.05).

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参芪注射液加益生菌改善胃癌部分切除术后患者的营养状况。
近年来,胃癌(gastric cancer, GC)的发病率呈上升趋势,手术通常需要切除部分与肿瘤病灶相连的胃组织,导致患者术后健康状况不佳,预后不良。益生菌作为一种活性微生物,在改善胃肠功能、增强免疫力等方面发挥着重要作用。在本研究中,我们将135例胃癌患者随机分为对照组、益生菌组和联合组。所有研究对象均在我院行根治性胃癌切除术。术后对照组给予常规治疗,益生菌组给予常规治疗+益生菌,联合组给予常规治疗+益生菌+参芪注射液。通过研究,我们发现,与常规肠内营养悬浮液治疗的患者相比,使用益生菌后,胃癌患者术后康复过程明显缩短,免疫功能和营养状况得到有效改善,预后生存率提高。此外,联合组患者CD4+、ALB、HGB、PA、TP均高于益生菌组(P
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来源期刊
CiteScore
1.40
自引率
12.50%
发文量
211
审稿时长
4.5 months
期刊介绍: Pakistan Journal of Pharmaceutical Sciences (PJPS) is a peer reviewed multi-disciplinary pharmaceutical sciences journal. The PJPS had its origin in 1988 from the Faculty of Pharmacy, University of Karachi as a biannual journal, frequency converted as quarterly in 2005, and now PJPS is being published as bi-monthly from January 2013. PJPS covers Biological, Pharmaceutical and Medicinal Research (Drug Delivery, Pharmacy Management, Molecular Biology, Biochemical, Pharmacology, Pharmacokinetics, Phytochemical, Bio-analytical, Therapeutics, Biotechnology and research on nano particles.
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