Jiaqiong Sun, Guangfan Zheng, Ge Zhang, Yan Li, Qian Zhang
{"title":"Recent advances in enantioselective construction of C–N bonds involving radical intermediate","authors":"Jiaqiong Sun, Guangfan Zheng, Ge Zhang, Yan Li, Qian Zhang","doi":"10.1039/d4qo02268h","DOIUrl":null,"url":null,"abstract":"This review offers a comprehensive overview of recent advancements in the asymmetric construction of C–N bonds involving radical intermediates. Enantioselective radical amination strategies have proven to be highly effective for synthesizing chiral amines and nitrogen-containing heterocycles. Significant progress has been made in the enantioselective installation of N–containing groups into halogenated alkanes, alkanes, olefins, and dienes with asymmetric formation of C–N bonds as the key step via diversified pathways including reductive elimination, radical-polar crossover, amino group substitution, and radical-radical cross-coupling, etc. This review highlights these recent developments and the mechanistic insights that drive these transformations.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"43 1","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4qo02268h","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
This review offers a comprehensive overview of recent advancements in the asymmetric construction of C–N bonds involving radical intermediates. Enantioselective radical amination strategies have proven to be highly effective for synthesizing chiral amines and nitrogen-containing heterocycles. Significant progress has been made in the enantioselective installation of N–containing groups into halogenated alkanes, alkanes, olefins, and dienes with asymmetric formation of C–N bonds as the key step via diversified pathways including reductive elimination, radical-polar crossover, amino group substitution, and radical-radical cross-coupling, etc. This review highlights these recent developments and the mechanistic insights that drive these transformations.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.