{"title":"Regio- and Stereoselective β-C(sp3)‒H Activation/ Functionalization of Saturated Nitrogen Heterocycles, Amines and Amides","authors":"Sanjay Yadav, Murugesh V, Surisetti Suresh","doi":"10.1002/adsc.202401398","DOIUrl":null,"url":null,"abstract":"Regio- and stereoselective β-C(sp3)‒H bond functionalizations of saturated nitrogen heterocycles, amines/amides are challenging and have emerged as an important topic of research in the area of C(sp3)‒H activation. Herein, we have summarized various β-C(sp3)‒H activation/functionalization methods; this review provides an overview of various trending approaches for β-C(sp3)‒H bond activation/functionalization of saturated nitrogen heterocycles, amines/amides. The regio- and stereoselective β-C(sp3)‒H bond activation methods are classified based on the reaction pathways. The literature methods including directing group or ligand-assisted reactions, reactions proceeding through enamine intermediate, redox-neutral methods and other trending methods including photoredox and transitional metal-free methods are discussed with recent updates.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"6 1","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/adsc.202401398","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Regio- and stereoselective β-C(sp3)‒H bond functionalizations of saturated nitrogen heterocycles, amines/amides are challenging and have emerged as an important topic of research in the area of C(sp3)‒H activation. Herein, we have summarized various β-C(sp3)‒H activation/functionalization methods; this review provides an overview of various trending approaches for β-C(sp3)‒H bond activation/functionalization of saturated nitrogen heterocycles, amines/amides. The regio- and stereoselective β-C(sp3)‒H bond activation methods are classified based on the reaction pathways. The literature methods including directing group or ligand-assisted reactions, reactions proceeding through enamine intermediate, redox-neutral methods and other trending methods including photoredox and transitional metal-free methods are discussed with recent updates.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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