Yueyue Lei , Dawei Xu , Yuexuan Wang , Shiwen Guo , Lujun Li , Mengyin Luo , Xu Li , Xinyi Liu , Chunyang Shi
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引用次数: 0
Abstract
Previously undescribed triterpenoid saponins (1–8), along with eight previously reported analogues (9–16), were isolated from an EtOAc extract obtained from the roots of Rubus setchuenensis. Structures were established based on HRESIMS, 1D and 2D NMR, as well as by literature comparisons. All compounds were isolated for the first time from the genus Rubus. Compounds 3–4, 6–8, and 12–15 displayed inhibitory activities against NO production in a RAW264.7 cell inflammation model induced by LPS. Moreover, 4, 6–8, and 12–13 exhibited inhibitory effects in a LPS-induced BV-2 cell neuroinflammation model.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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