Accommodation microfluctuation in individuals with mTBI and the potential effect of chromatic filter on this parameter.

IF 1.5 4区心理学 Q4 NEUROSCIENCES Vision Research Pub Date : 2025-01-19 DOI:10.1016/j.visres.2025.108545

Nawaf M Almutairi, John Hayes, Karen M Hampson, Chunming Liu

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Abstract

Individuals with mild traumatic brain injury (mTBI) exhibit significant accommodative abnormalities. Accommodation microfluctuation (MFs) plays an important role in the accommodation steady-state control. This study was set to investigate the characteristics of the MFs in mTBI subjects and whether chromatic filter (CF) or neutral density filter (ND) would impact these parameters. 54 healthy and 30 mTBI young adults participated. Tonic accommodation (TA) was recorded in complete darkness after dark adaptation. The steady-state accommodation response (AR) for various stimulus distances was recorded at baseline (no filter; NF), with CF and ND. The low and high frequency component (LFC and HFC respectively) of MFs was analyzed. Subjects with mTBI exhibited significantly lower MFs, especially at higher stimulus levels. There was a strong negative correlation between the accommodation error (AE) and the LFC. Increased lag of accommodation (AE > 0 D) was associated with lower LFC and vice versa. Both filter conditions exerted a minimum impact on the MFs overall. A strong positive correlation between MFs and TA was revealed for both groups. Our study showed that mTBI significantly impaired the MFs of accommodation. The observed lower MFs power in mTBI appears to be subsequent to the higher lag of accommodation, suggesting an underlying deficit in the accommodative motor controller to generate sufficient response. The strong correlation between TA and MFs, as well as the lack of effect from different filters, further supports the theory that sensory blur detection does not play a significant role in MFs of accommodation.

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mTBI患者的调节微波动及色度滤波器对该参数的潜在影响。

轻度创伤性脑损伤（mTBI）患者表现出明显的适应性异常。调节微波动在调节稳态控制中起着重要的作用。本研究旨在探讨mTBI受试者的MFs特征，以及彩色滤光器（CF）或中性密度滤光器（ND）是否会影响这些参数。54名健康青年和30名mTBI青年参与了研究。暗适应后，在完全黑暗条件下记录补适性（TA）。记录不同刺激距离下的稳态调节响应（AR）(无滤波器；NF)， CF和ND。分析了MFs的低频和高频成分（LFC和HFC）。mTBI受试者表现出明显较低的MFs，特别是在高刺激水平下。调节误差（AE）与LFC之间存在较强的负相关。调节滞后增加（AE b> 0 D）与LFC降低相关，反之亦然。两种过滤条件对总体MFs的影响都很小。两组的MFs与TA呈正相关。我们的研究表明，mTBI显著损害了适应的MFs。mTBI中观察到的较低的mf功率似乎是在调节的较高滞后之后出现的，这表明调节电机控制器存在潜在的缺陷，无法产生足够的响应。TA和MFs之间的强相关性，以及不同过滤器的影响不足，进一步支持了感觉模糊检测在调节的MFs中不起重要作用的理论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vision Research 医学-神经科学

CiteScore

3.70

自引率

16.70%

发文量

111

审稿时长

66 days

期刊介绍： Vision Research is a journal devoted to the functional aspects of human, vertebrate and invertebrate vision and publishes experimental and observational studies, reviews, and theoretical and computational analyses. Vision Research also publishes clinical studies relevant to normal visual function and basic research relevant to visual dysfunction or its clinical investigation. Functional aspects of vision is interpreted broadly, ranging from molecular and cellular function to perception and behavior. Detailed descriptions are encouraged but enough introductory background should be included for non-specialists. Theoretical and computational papers should give a sense of order to the facts or point to new verifiable observations. Papers dealing with questions in the history of vision science should stress the development of ideas in the field.