Talia Salzman, Erica Laurin, Chloe Thibault, Peter Farrell, Sarah Fraser
{"title":"A systematic review and meta-analysis of dual-task outcomes in subjective cognitive decline.","authors":"Talia Salzman, Erica Laurin, Chloe Thibault, Peter Farrell, Sarah Fraser","doi":"10.1002/dad2.70054","DOIUrl":null,"url":null,"abstract":"<p><p>Subjective cognitive decline (SCD) may represent a preclinical manifestation of objective cognitive impairment. This review consolidated existing findings to determine if dual-tasks objectively differentiate between individuals with SCD, motoric cognitive risk syndrome (MCR), mild cognitive impairment (MCI), and dementia. MEDLINE, Embase, PsycINFO, CENTRAL, AgeLine, and CINAHL were systematically searched for dual-task studies examining older adults with SCD and analyzed using random-effects meta-analyses. Thirteen studies met the inclusion criteria. Within the SCD group, faster gait speed (SMD, 1.35; 95% CI, 0.57-2.13; <i>p </i>= .0007) and longer step length (SMD, 0.85; 95% CI, 0.44-1.26; <i>p </i>< .0001) favored the single compared to dual-task condition. Faster gait speed was observed in the SCD group compared to MCI (SMD, 0.48; 95% CI, 0.28-0.67; <i>p </i>= .0001). A standardized dual-task approach is needed to track gait parameters longitudinally, beginning with changes occurring at the SCD stage as these may precede future cognitive impairments.</p><p><strong>Highlights: </strong>Evidence demonstrates that SCD may be a precursor to dementia.Faster dual-task gait speed was observed in the SCD group compared to MCI.Slower dual-task gait speed and shorter step length were observed within the SCD group.Dual-tasks may help differentiate between preclinical and clinical cognitive decline.Dual-tasks should be standardized and changes should be tracked longitudinally.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e70054"},"PeriodicalIF":4.0000,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736712/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/dad2.70054","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Subjective cognitive decline (SCD) may represent a preclinical manifestation of objective cognitive impairment. This review consolidated existing findings to determine if dual-tasks objectively differentiate between individuals with SCD, motoric cognitive risk syndrome (MCR), mild cognitive impairment (MCI), and dementia. MEDLINE, Embase, PsycINFO, CENTRAL, AgeLine, and CINAHL were systematically searched for dual-task studies examining older adults with SCD and analyzed using random-effects meta-analyses. Thirteen studies met the inclusion criteria. Within the SCD group, faster gait speed (SMD, 1.35; 95% CI, 0.57-2.13; p = .0007) and longer step length (SMD, 0.85; 95% CI, 0.44-1.26; p < .0001) favored the single compared to dual-task condition. Faster gait speed was observed in the SCD group compared to MCI (SMD, 0.48; 95% CI, 0.28-0.67; p = .0001). A standardized dual-task approach is needed to track gait parameters longitudinally, beginning with changes occurring at the SCD stage as these may precede future cognitive impairments.
Highlights: Evidence demonstrates that SCD may be a precursor to dementia.Faster dual-task gait speed was observed in the SCD group compared to MCI.Slower dual-task gait speed and shorter step length were observed within the SCD group.Dual-tasks may help differentiate between preclinical and clinical cognitive decline.Dual-tasks should be standardized and changes should be tracked longitudinally.
期刊介绍：
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
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